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Many studies have suggested that testosterone and anabolic steroids affect the functioning of the central nervous system (CNS)and therefore have an impact on various cognitive functions. The CNS is an organ that governs functions such as consciousness and motor control through a network of brain structures and neural mechanisms. It also incorporates various sensory, emotional, and somatic organs as well as the central circadian mechanism, which is responsible for circadian rhythms, sleep, appetite and metabolism and serves as an energy-sourcing organ. Recent studies have suggested that anabolic steroids may affect the CNS by altering certain neurotransmitter systems and may modulate mood. The review examined several neurotransmitter systems, including: monoamine oxidase (MAO), 5-hydroxytryptamine (5-HT), serotonin (5-HT) and dopamine (DA). The review also discusses the different mechanisms whereby anabolic steroids may influence the brain, including the following: (1) the direct actions of anabolic steroids on central nervous system pathways; (2) the effects of anabolic steroids on specific neurotransmitter systems; and (3) the various factors that affect the effects of anabolic steroids on the brain, and may even affect a range of symptoms and signs. Reviews by this author are published in the medical press and often are referred to as "authoritative views". Similar articles: